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Microbiology Research

The fact that microbes have an impact on the environment and humans has been demonstrated by many studies, and BGI has conducted a number of studies on microorganisms.
To further understand the mechanism of microbial metabolism, lay the foundation for exploring the regulatory mechanism of gene expression and signal transduction at the overall level.

Yeast genome Sc2.0 project

Yeast genome Sc2.0 project aims to build the world first eukaryotic organism from scratch. While this project can help us to understand the modern organism on a whole new level, it also promotes the potential applications in many fields, such as biomanufacture and bio-medicine.

Detailed introduction：

Synthetic genomics allows the redesign of life based on our understanding and intention, In 2011, researchers from US, China, UK, Singapore and Australia together innitiated the internationsl collaboration project Yeast Sc2.0. As one of the three Chinese groups in this community, BGI deeply involed in this project. In 2017, the community finished the design and synthesis of five chromosomes of yeast, and published as a special issue and cover story of Science. Several fundamental strategies for chromosome construction and Omics analysis were established. In 2018, the community published 7 papers as the second special issue of Nature Communications and showed various applications based on synthetic yeast.

Publications：

1.Shen Y, Wang Y, Chen T, et al. Deep functional analysis of synII, a 770-kilobase synthetic yeast chromosome. Science, 2017, 355(6329).

2.Zhang W, Zhao G, Luo Z, et al. Engineering the ribosomal DNA in a megabase synthetic chromosome. Science, 2017, 355(6329): 1-7.

3.Mercy G, Mozziconacci J, Scolari V F, et al. 3D organization of synthetic and scrambled chromosomes. Science, 2017, 355(6329).

4.Mitchell L A, Wang A, Stracquadanio G, et al. Synthesis, debugging, and effects of synthetic chromosome consolidation: synVI and beyond. Science, 2017, 355(6329).

5.Richardson S M, Mitchell L A, Stracquadanio G, et al. Design of a synthetic yeast genome. Science, 2017, 355(6329): 1040-1044.

6.Wu Y, Li B, Zhao M, et al. Bug mapping and fitness testing of chemically synthesized chromosome X. Science, 2017, 355(6329): 1-6.

7.Xie Z X, Li B, Mitchell L A, et al. “Perfect” designer chromosome V and behavior of a ring derivative. Science, 2017, 355(6329).

8.Luo Z, Wang L, Wang Y, et al. Identifying and characterizing SCRaMbLEd synthetic yeast using ReSCuES.[J]. Nature Communications, 2018, 9(1).

9.Liu, W., Luo, Z., Wang, Y., et al. (2018). Rapid pathway prototyping and engineering using in vitro and in vivo synthetic genome SCRaMbLE-in methods. Nature communications, 9(1), 1936.

10.Jia B, Wu Y, Li B, et al. Precise control of SCRaMbLE in synthetic haploid and diploid yeast. Nature Communications, 2018, 9(1): 1933.

11.Blount B A, Gowers G F, Ho J C, et al. Rapid host strain improvement by in vivo rearrangement of a synthetic yeast chromosome. Nature Communications, 2018, 9(1): 1932.

12.Shen M J, Wu Y, Yang K, et al. Heterozygous diploid and interspecies SCRaMbLEing. Nature Communications, 2018, 9(1): 1934.

13.Wu Y, Zhu R Y, Mitchell L A, et al. In vitro DNA SCRaMbLE. Nature Communications, 2018, 9(1).

14.Hochrein L, Mitchell L A, Schulz K, et al. L-SCRaMbLE as a tool for light-controlled Cre-mediated recombination in yeast. Nature Communications, 2018, 9(1).

15.Shen Y, Stracquadanio G, Wang Y, et al. SCRaMbLE generates designed combinatorial stochastic diversity in synthetic chromosomes. Genome Research, 2016, 26(1): 36-49.